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Methylation is responsible for making, maintaining and repairing DNA

Methylation is the process where nutrients called ‘methyl donors’ are added to our gene markers and proteins to keep them active. Vitamins B12 and folate play important roles in this process. Testing of the cofactors Methylmalonic acid (MMA) and Formiminoglutamic acid (FIGLU) is more effective than measuring the levels of the B vitamins themselves - this is because impaired methylation can cause these vitamins to build up in the blood where they are measured, but the vitamins can't get into the cells where they are needed.

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Understanding your B vitamin levels are especially important if you have elevated homocysteine levels. Elevated homocysteine is a risk factor for cardiovascular disease. It is a multifactorial condition with genetic and environmental factors involved, and can often be managed providing there are sufficient B vitamins.

What we test

Methylation Cofactors

Elevated MMA is associated with Vitamin B12 deficiency, and elevated levels of FIGLU are associated with a deficiency of folic acid. Testing of these cofactors is more effective than measuring the levels of the vitamins themselves - this is because impaired methylation can cause these vitamins to build up in the blood where they are measured, but the vitamins can't get into the cells where they are needed.

This urine spot test measures

Elevated MMA is associated with Vitamin B12 deficiency

Elevated levels of FIGLU are associated with a deficiency of folic acid

A waste molecule generated from muscle metabolism, and an accurate marker of kidney function.

Test instructions

Your test kit and all instructions are posted directly to you, and there is no need to visit a collection centre.

Results for this test available in 1-2 weeks and will be published in your online dashboard.

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